RT journal article
T1 Migratory Response of Cells in Neurogenic Niches to Neuronal Death: The Onset of Harmonic Repair?
A1 Geribaldi Doldán, Noelia
A1 Carrascal, Livia
A1 Pérez García, Patricia
A1 Oliva Montero, José María
A1 Pardillo Díaz, Ricardo
A1 Domínguez García, Samuel
A1 Bernal Utrera, Carlos
A1 Gómez Oliva, Ricardo
A1 Martínez Ortega, Sergio
A1 Verástegui Escolano, Cristina
A1 Nunez Abades, Pedro
A1 Castro González, Carmen
A2 Anatomía y Embriología Humana
A2 BiomedicinaBiotecnología y Salud Pública
K1 Alzheimer’s disease
K1 brain injury and stroke
K1 epilepsy
K1 Huntington’s disease
K1 neuroblast migration
K1 neurogenesis
K1 Parkinson’s disease
AB Harmonic mechanisms orchestrate neurogenesis in the healthy brain within specific neurogenic niches, which generate neurons from neural stem cells as a homeostatic mechanism. These newly generated neurons integrate into existing neuronal circuits to participate in different brain tasks. Despite the mechanisms that protect the mammalian brain, this organ is susceptible to many different types of damage that result in the loss of neuronal tissue and therefore in alterations in the functionality of the affected regions. Nevertheless, the mammalian brain has developed mechanisms to respond to these injuries, potentiating its capacity to generate new neurons from neural stem cells and altering the homeostatic processes that occur in neurogenic niches. These alterations may lead to the generation of new neurons within the damaged brain regions. Notwithstanding, the activation of these repair mechanisms, regeneration of neuronal tissue within brain injuries does not naturally occur. In this review, we discuss how the different neurogenic niches respond to different types of brain injuries, focusing on the capacity of the progenitors generated in these niches to migrate to the injured regions and activate repair mechanisms. We conclude that the search for pharmacological drugs that stimulate the migration of newly generated neurons to brain injuries may result in the development of therapies to repair the damaged brain tissue.
PB MDPI
SN 1661-6596
YR 2023
FD 2023-04-01
LK http://hdl.handle.net/10498/31828
UL http://hdl.handle.net/10498/31828
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 08-nov-2026