RT journal article
T1 Metabolic Disturbance of High-Saturated Fatty Acid Diet in Cognitive Preservation
A1 Rivas Domínguez, Antonio
A1 Mohamed Mohamed, Himan
A1 Jiménez Palomares, Margarita
A1 García Morales, Victoria
A1 Martínez López, Laura
A1 Orta, Manuel Luis
A1 Ramos Rodríguez, Juan José
A1 Bermúdez Pulgarin, Beatriz
A2 BiomedicinaBiotecnología y Salud Pública
K1 cognition
K1 dementia
K1 episodic memory hyperlipidemia
K1 HFD
K1 insulin resistance
K1 LDL
K1 LDLR
K1 saturated fatty acid
AB Aging continues to be the main cause of the development of Alzheimer’s, although it has been described that certain chronic inflammatory pathologies can negatively influence the progress of dementia, including obesity and hyperlipidemia. In this sense, previous studies have shown a relationship between low-density lipoprotein receptor (LDLR) and the amyloid-beta (Aβ) binding activity, one of the main neuropathological features of Alzheimer’s disease (AD). LDLR is involved in several processes, including lipid transport, regulation of inflammatory response and lipid metabolism. From this perspective, LDLR−/− mice are a widely accepted animal model for the study of pathologies associated with alterations in lipid metabolism, such as familial hypercholesterolemia, cardiovascular diseases, metabolic syndrome, or early cognitive decline. In this context, we induced hyperlipidemia in LDLR−/− mice after feeding with a high-saturated fatty acid diet (HFD) for 44 weeks. LDLR−/−-HFD mice exhibited obesity, hypertriglyceridemia, higher glucose levels, and early hepatic steatosis. In addition, HFD increased plasmatic APOE and ubiquitin 60S levels. These proteins are related to neuronal integrity and health maintenance. In agreement, we detected mild cognitive dysfunctions in mice fed with HFD, whereas LDLR−/−-HFD mice showed a more severe and evident affectation. Our data suggest central nervous system dysfunction is associated with a well-established metabolic syndrome. As a late consequence, metabolic syndrome boots many behavioral and pathological alterations recognized in dementia, supporting that the control of metabolic parameters could improve cognitive preservation and prognosis
PB MDPI
SN 1661-6596
YR 2023
FD 2023-04-28
LK http://hdl.handle.net/10498/31830
UL http://hdl.handle.net/10498/31830
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 08-nov-2026