RT journal article
T1 From Cell to Symptoms: The Role of SARS-CoV-2 Cytopathic Effects in the Pathogenesis of COVID-19 and Long COVID
A1 González García, Pablo
A1 Fiorillo Moreno, Ornella
A1 Zarate Peñata, Eloina
A1 Calderón Villalba, Alejandro
A1 Pacheco Lugo, Lisandro
A1 Acosta Hoyos, Antonio
A1 Villarreal Camacho, José Luis
A1 Navarro Quiroz, Roberto
A1 Pacheco Londoño, Leonardo
A1 Aroca Martínez, Gustavo
A1 Moares Fernández, Noelia del Carmen
A1 Gabucio López, Antonio
A1 Fernández Ponce, Cecilia Matilde
A1 García Cózar, Francisco José
A1 Navarro Quiroz, Elkin
A2 BiomedicinaBiotecnología y Salud Pública
K1 angiotensin-converting enzyme 2
K1 cell dysfunction
K1 coronavirus
K1 COVID-19
K1 cytokine storm
K1 ytopathy
K1 long COVID
K1 PASC
K1 SARS-CoV-2
K1 sequelae
AB Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection triggers various events from molecular to tissue level, which in turn is given by the intrinsic characteristics of each patient. Given the molecular diversity characteristic of each cellular phenotype, the possible cytopathic, tissue and clinical effects are difficult to predict, which determines the heterogeneity of COVID-19 symptoms. The purpose of this article is to provide a comprehensive review of the cytopathic effects of SARS-CoV-2 on various cell types, focusing on the development of COVID-19, which in turn may lead, in some patients, to a persistence of symptoms after recovery from the disease, a condition known as long COVID. We describe the molecular mechanisms underlying virus-host interactions, including alterations in protein expression, intracellular signaling pathways, and immune responses. In particular, the article highlights the potential impact of these cytopathies on cellular function and clinical outcomes, such as immune dysregulation, neuropsychiatric disorders, and organ damage. The article concludes by discussing future directions for research and implications for the management and treatment of COVID-19 and long COVID.
PB MDPI
SN 1661-6596
YR 2023
FD 2023-05-05
LK http://hdl.handle.net/10498/31831
UL http://hdl.handle.net/10498/31831
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 21-sep-2026