RT journal article
T1 Amyotrophic Lateral Sclerosis and Serum Lipid Level Association: A Systematic Review and Meta-Analytic Study
A1 Pardo Moreno, Teresa
A1 Mohamed Mohamed, Himan
A1 Suleiman Martos, Sami
A1 Ramos Rodríguez, Juan José
A1 Rivas Domínguez, Antonio
A1 Melguizo Rodríguez, Lucía
A1 Gómez Urquiza, José L.
A1 Bermúdez Pulgarin, Beatriz
A1 García Morales, Victoria
A2 BiomedicinaBiotecnología y Salud Pública
K1 amyotrophic lateral sclerosis
K1 cholesterol
K1 lipids
K1 meta-analysis
K1 neurodegeneration
AB Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with unknown etiology. Many metabolic alterations occur during ALS progress and can be used as a method of pre-diagnostic and early diagnosis. Dyslipidemia is one of the physiological changes observed in numerous ALS patients. The aim of this study is to analyze the possible relationship between the rate of disease progression (functional rating scale (ALS-FRS)) and the plasma lipid levels at the early stage of ALS. A systematic review was carried out in July 2022. The search equation was “Triglycerides AND amyotrophic lateral sclerosis” and its variants. Four meta-analyses were performed. Four studies were included in the meta-analysis. No significant differences were observed between the lipid levels (total cholesterol, triglycerides, HDL cholesterol, and LDL cholesterol) and the ALS-FRS score at the onset of the disease. Although the number of studies included in this research was low, the results of this meta-analytic study suggest that there is no clear relationship between the symptoms observed in ALS patients and the plasma lipid levels. An increase in research, as well as an expansion of the geographical area, would be of interest.
PB MDPI
SN 1661-6596
YR 2023
FD 2023-05-12
LK http://hdl.handle.net/10498/31832
UL http://hdl.handle.net/10498/31832
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 08-nov-2026