RT journal article
T1 Dose-response association between cardiovascular health and mortality in cancer survivors
A1 López Bueno, Rubén
A1 Yang, Lin
A1 Calatayud, Joaquín
A1 Andersen, Lars Louis
A1 Pozo Cruz, Borja del
A2 Didáctica de la Educación FísicaPlástica y Musical
K1 Life expectancy
K1 Lifestyle
K1 Oncology
K1 Cardiology
K1 Preventive medicine
K1 Public health
AB Background: There is little knowledge on the dose-response association between cardiovascular health (CVH) and risk of all-cause, cardiovascular disease (CVD) and cancer deaths among cancer survivors. Aims: We aimed to examine the dose-response association of CVH with all-cause, CVD, and cancer mortality. Methods: A total of 1701 US adult cancer survivors were followed-up during a median of 7.3 (IQR 4.0-10.2) years from 2007 to 2018 through the National Health and Nutrition Examination Survey (NHANES). We used the American Heart Association´s (AHA) Life´s Essential 8 (LE8) as a proxy for CVH. Results: Restricted cubic spline models indicated a close to inverse linear shape for the dose-response association between LE8 score and all-cause mortality with significant risk reductions within the range between 61.25 (Hazard ratio [HR]: 0.76, 95% CI, 0.59-0.98) and 100 points (HR: 0.28, 95%CI, 0.12-0.62), and a curvilinear shape for the dose-response association between LE8 score and CVD deaths with significant risk reductions within the range between 50.25 (HR: 0.72, 95% CI, 0.52-0.99) and 90.25 points (HR: 0.15, 95%CI, 0.02-0.98). No significant dose-response association was observed between LE8 and cancer deaths. Conclusions: Our study showed a close to inverse relationship between higher LE8 and risk of death from all cause, an inverse curvilinear relationship between higher LE8 and the risk for CVD death, and a non-significant association between higher LE8 and the risk of cancer death among US adult cancer survivors, which may translate to a substantial number of annual averted deaths and thus important public health implications.
PB Elsevier Inc.
SN 1535-6280
YR 2024
FD 2024
LK http://hdl.handle.net/10498/31843
UL http://hdl.handle.net/10498/31843
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 09-may-2026