RT journal article
T1 Value of NT-proBNP and Galectin-3 as Biomarkers in the Follow-Up of Asymptomatic Elderly Patients with Severe Aortic Stenosis
A1 Ramos, Mónica
A1 Quezada-Feijoó, Maribel
A1 Ayala, Rocío
A1 Manzano, Ascención
A1 Gómez-Pavón, Francisco Javier
A1 Jaramillo, Javier
A1 Herrera, Cristina
A1 López Vazquez de la Torre, Mariola
A1 Toro Cebada, Rocío
A2 Cirugía
A2 Medicina
K1 aortic stenosis
K1 older patients
K1 congestive heart failure
K1 Galectin-3
K1 NT-proBNP
AB Recognizing symptoms in elderly patients with severe aortic stenosis (AS) can be a challenge.Serum biomarkers such as Galectin-3 or N-terminal prohormone B-type natriuretic peptide(NT-proBNP) are involved in remodeling and heart failure (HF) development and could supportthe diagnosis of AS. We set out to test the usefulness of NT-proBNP and Galectin-3 in predictingevents in this population. We designed a prospective observational case–control study, including50 asymptomatic patients older than 70 years, diagnosed with severe degenerative AS, and 50 controlindividuals. The NT-proBNP and Galectin-3 levels were measured. A follow-up was carriedout at 12 months to determine the occurrence of hospital admission for HF, all-cause mortality orthe appearance of symptoms. The patients with severe AS had higher Galectin-3 and NT-proBNPconcentrations. The area under the receiver operating characteristic curve of the NT-proBNP was0.812 (95% CI, 0.646–0.832), and that of the Galectin-3 was 0.633 (95% CI, 0.711–0.913). NT-proBNPwas a good predictor of events [HR 3.45 (95% CI 1.32–9.03), p = 0.011]. A Kaplan–Meier analysisshowed that the probability of freedom from events was significant in patients who exhibited acombination of higher NT-proBNP and Galectin-3 levels (log-rank p = 0.032). Therefore, NT-proBNPwas the most reliable predictor of events in asymptomatic patients with severe AS. A combination ofNT-proBNP and Galectin-3 levels may be vital in the clinical follow-up of these patients and in thedecision-making process.
PB MDPI
SN 2077-0383
YR 2023
FD 2023
LK http://hdl.handle.net/10498/31955
UL http://hdl.handle.net/10498/31955
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026