RT journal article
T1 Anticipatory Antifungal Treatment in Critically Ill Patients with SARS-CoV-2 Pneumonia
A1 Estella García, Angel
A1 Recuerda Núñez, María
A1 Lagares Franco, Carolina María
A1 Gracia Romero, Manuel Angel
A1 Torres, Eva
A1 Alados Arboledas, Juan Carlos
A1 Antón Escors, Álvaro
A1 González García, Clara
A1 Sandar Núñez, Dolores
A1 López Prieto, Dolores
A1 Sánchez Calvo, Juan Manuel
A2 Anatomía y Embriología Humana
A2 BiomedicinaBiotecnología y Salud Pública
A2 Cirugía
A2 Estadística e Investigación Operativa
A2 Medicina
K1 SARS-CoV-2
K1 liposomal amphotericin B
K1 ARDS
K1 aspergillus
K1 bronchoalveolar lavage
K1 ICU
AB Background. The aim of this study was to investigate the incidence of COVID-19-associatedpulmonary aspergillosis (CAPA) in critically ill patients and the impact of anticipatory antifungaltreatment on the incidence of CAPA in critically ill patients. Methods. Before/after observationalstudy in a mixed intensive care unit (ICU) of a university teaching hospital. The study took placebetween March 2020 and June 2022. Inclusion criteria were critically ill patients with severe SARSCoV-2 pneumonia requiring invasive mechanical ventilation. Two analysis periods were comparedaccording to whether or not antifungal therapy was given early. Results. A total of 160 patients withsevere SARS-CoV-2 pneumonia and invasive mechanical ventilation were included. The incidenceof CAPA in the first study period was 19 out of 58 patients (32.75%); during the second period,after implementation of the intervention (anticipatory antifungal therapy), the incidence of CAPAdecreased to 10.78% (11 out of 102 patients). In patients with CAPA under invasive mechanicalventilation, the mortality rate decreased from 100% to 64%. Conclusions. Anticipating antifungaltreatment in patients with SARS-CoV-2 pneumonia under invasive mechanical ventilation wasassociated with a decrease in the incidence and mortality of pulmonary aspergillosis.
PB MDPI
SN 2309-608X
YR 2023
FD 2023
LK http://hdl.handle.net/10498/32025
UL http://hdl.handle.net/10498/32025
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 06-nov-2026