RT journal article
T1 Formation of PLGA–PEDOT: PSS Conductive Scaffolds by Supercritical Foaming
A1 Montes Herrera, Antonio
A1 Valor López, Diego
A1 Penabad, Yaiza
A1 Domínguez de la Vega, Manuel
A1 Pereyra López, Clara María
A1 Martínez de la Ossa Fernández, Enrique José
A2 Física de la Materia Condensada
A2 Ingeniería Química y Tecnología de Alimentos
K1 supercritical foaming
K1 conductive; polymer
K1 porosity
K1 PLGA
AB The usage of conjugated materials for the fabrication of foams intended to be used astherapeutic scaffolds is gaining relevance these days, as they hold certain properties that are notexhibited by other polymer types that have been regularly used until the present. Hence, this workaims to design a specific supercritical CO2foaming process that would allow the production ofporous polymeric devices with improved conductive properties, which would better simulate matrixextracellular conditions when used as therapeutic scaffolds (PLGA–PEDOT:PSS) systems. The effectsof pressure, temperature, and contact time on the expansion factor, porosity, mechanical properties,and conductivity of the foam have been evaluated. The foams have been characterized by scanningelectron and atomic force microscopies, liquid displacement, PBS degradation test, compression, andresistance to conductivity techniques. Values close to 40% porosity were obtained, with a uniformdistribution of polymers on the surface and in the interior, expansion factors of up to 10 orders, and awide range of conductivity values (2.2 × 10−7to 1.0 × 10−5 S/cm) and mechanical properties (0.8 to13.6 MPa Young’s modulus in compression test). The conductive and porous scaffolds that havebeen produced by supercritical CO2in this study show an interesting potential for tissue engineeringand for neural or cardiac tissue regeneration purposes due to the fact that electrical conductivity is acrucial factor for proper cell function and tissue development.
PB MDPI
SN 1996-1944
YR 2023
FD 2023
LK http://hdl.handle.net/10498/32044
UL http://hdl.handle.net/10498/32044
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026