RT journal article
T1 Treatment of Severe Atopic Dermatitis With Upadacitinib in Clinical Practice: Short-Term Efficacy and Safety Results
A1 Pereyra Rodríguez, J. J.
A1 Herranz, P.
A1 Figueras Nart, I.
A1 Pérez, B.
A1 Elosua, M.
A1 Munera Campos, M.
A1 Melgosa Ramos, J.
A1 Zaragoza, V.
A1 Silvestre, J. F.
A1 Campos Domínguez, M.
A1 Guilabert, A.
A1 Miquel, J.
A1 Alcantara Luna, S.
A1 de la Cueva, P.
A1 Serra Baldrich, E.
A1 Armario Hita, José Carlos
A2 Medicina
K1 Atopic dermatitis
K1 Atopic eczema
K1 Upadacitinib
K1 JAK-inhibitors
K1 Real-world evidence
AB Introduction: Death with a functioning graft (DWFG) is the most frequent cause of loss of kidney transplantation (KT).Objective: To analyze the evolution of the causes of DWFG and the frequency of the types of cancer causing DWFG.Methods: Retrospective study of KT in Andalusia from 1984 to 2018. We analyzed the evolution according to eras (1984-1995; 1996-2007; 2008-2018) and according to post-transplant period (early death: first year post-KT; late death: after first year post-KT).Results: A total of 9905 KT were performed, registering 1861 DWFG. The most frequent causes were cardiovascular disease (25.1%), infections (21.5%) and cancer (19.9%). In early death we did not observe changes, and infections were always the main cause. In late death, cardiovascular death decreased (1984-1995: 35.2%, 1996-2007: 22.6%, 2008-2018: 23.9%), but infections (1984-1995: 12.5%, 1996-2007: 18.3%, 2008-2018: 19.9%) and, above all, cancer-related deaths increased (1984-1995: 21.8%, 1996-2007: 29%, 2008-2018: 26.8%) (P < .001). In the multivariable analysis for late death due to cardiovascular disease, recipient age, retransplantation, diabetes, and the first period were risk factors, while the risk of late death due to cancer and infections was associated with recent eras. In the first year after transplantation, the most frequent neoplasia causing DWFG was post-transplant lymphoproliferative disease, and after the first year, it was lung cancer, without differences when it was analyzed by eras.Conclusions: Despite the greater comorbidity of the recipients, cardiovascular deaths have decreased. Cancer has been the main cause of late death in recent years. Lung cancer is the most frequent malignancy that causes DWFG in our transplant patients.
PB Esmon Publicidad
SN 1698-0808
YR 2022
FD 2022-06-01
LK http://hdl.handle.net/10498/32142
UL http://hdl.handle.net/10498/32142
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 13-nov-2026