RT journal article
T1 Symptom- related screening programme for early detection of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism: the SYSPPE study
A1 Marin-Romero, Samira
A1 Ballaz-Quincoces, Aitor
A1 Gómez Cuervo, Covadonga
A1 Marchena Yglesias, Pablo Javier
A1 López Miguel, Patricia
A1 Francisco-Albesa, Iria
A1 Pedrajas Navas, Jose Maria
A1 Lumbierres, Marina
A1 Aibar-Arregui, Miguel Angel
A1 López Sáez, José Juan Bosco
A1 Perez Pina, Montserrat
A1 Baeza Martinez, Carlos
A1 Riera Mestre, Antoni
A1 Peris Sifre, Marisa
A1 Porras Ledantes, Jose Antonio
A1 Criado Garcia, Juan
A1 Elias-Hernandez, Teresa
A1 Otero, Remedios
A1 Barca Hernando, Maria
A1 Muriel, Alfonso
A1 A Klo, Frederikus
A1 Jara-Palomares, Luis
A2 Medicina
AB Background Chronic thromboembolic pulmonary hypertension (CTEPH) is the most severe long- term complication of acute pulmonary embolism (PE). We aimed to evaluate the impact of a symptom screening programme to detect CTEPH in PE survivors. Methods This was a multicentre cohort study of patients diagnosed with acute symptomatic PE between January 2017 and December 2018 in 16 centres in Spain. Patients were contacted by phone 2 years after the index PE diagnosis. Those with dyspnoea corresponding to a New York Heart Association (NYHA)/WHO scale≥II, visited the outpatient clinic for echocardiography and further diagnostic tests including right heart catheterisation (RHC). The primary outcome was the new diagnosis of CTEPH confirmed by RHC. Results Out of 1077 patients with acute PE, 646 were included in the symptom screening. At 2 years, 21.8% (n=141) reported dyspnoea NYHA/WHO scale≥II. Before symptom screening protocol, five patients were diagnosed with CTEPH following routine care. In patients with NYHA/WHO scale≥II, after symptom screening protocol, the echocardiographic probability of pulmonary hypertension (PH) was low, intermediate and high in 76.6% (n=95), 21.8% (n=27) and 1.6% (n=2), respectively. After performing additional diagnostic test in the latter 2 groups, 12 additional CTEPH cases were confirmed. Conclusions The implementation of this simple strategy based on symptom evaluation by phone diagnosed more than doubled the number of CTEPH cases. Dedicated follow- up algorithms for PE survivors help diagnosing CTEPH earlier.
YR 2023
FD 2023-11-30
LK http://hdl.handle.net/10498/32255
UL http://hdl.handle.net/10498/32255
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 08-nov-2026