RT journal article
T1 Leisure-Time Physical Activity and Risk of Microvascular Complications in Individuals With Type 2 Diabetes: A UK Biobank Study
A1 Kristensen, F. P. B.
A1 Sánchez Lastra, M. A.
A1 Dalene, K. E.
A1 Pozo Cruz, Borja del
A1 Ried Larsen, M.
A2 Didáctica de la Educación FísicaPlástica y Musical
K1 Biological Specimen Banks
K1 Cohort Studies
K1 Diabetes Mellitus, Type 2
K1 Humans
K1 Leisure Activities
K1 Risk Factors
K1 United Kingdom
AB OBJECTIVE The aim of this study was to determine dose-response associations, including the minimal effective level, between leisure-time physical activity and risk of incident neuropathy, nephropathy, and retinopathy. RESEARCH DESIGN AND METHODS This cohort study included 18,092 individuals with type 2 diabetes from the UK Biobank. Self-reported leisure-time physical activity was converted into MET-hours per week. Participants were categorized into no physical activity (0 MET-h/week), below recommendations (0–7.49 MET-h/week), at recommendations (7.5–14.9 MET-h/week), and above recommendations (‡15 MET-h/week). Microvascular complications were identified from hospital inpatient records using diagnosis codes.We used Cox proportional hazards regression analysis to calculate adjusted hazard ratios (aHRs) and restricted cubic splines to identify theminimal effective level of physical activity. RESULTS During a median follow-up of 12.1 years, 672 individuals (3.7%) were diagnosed with neuropathy, 1,839 (10.2%) with nephropathy, and 2,099 (11.7%) with retinopathy. Any level of physical activity was associated with a lower risk of neuropathy and nephropathy but not retinopathy. Compared with those reporting no physical activity, the aHR of neuropathy was 0.71 (95% CI 0.53, 0.90) below recommendations, 0.73 (0.56, 0.96) at recommendations, and 0.67 (0.52, 0.87) above recommendations. Corresponding aHRs for nephropathy were 0.79 (0.68, 0.92), 0.80 (0.67, 0.95), and 0.80 (0.68, 0.95). The association with retinopathy was weaker, with aHRs of 0.91 (0.78, 1.06), 0.91 (0.77, 1.08), and 0.98 (0.84, 1.15), respectively. CONCLUSIONS Any level of leisure-time physical activity was associated with a lower risk of neuropathy and nephropathy but not retinopathy in individuals with type 2 diabetes. For both neuropathy and nephropathy, the minimal effective physical activity level may correspond to <1.5 h of walking per week. © 2023 by the American Diabetes Association. All rights reserved.
SN 1935-5548
YR 2023
FD 2023-06
LK http://hdl.handle.net/10498/32259
UL http://hdl.handle.net/10498/32259
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 09-may-2026