RT journal article
T1 Joint associations of device-measured physical activity and abdominal obesity with incident cardiovascular disease: a prospective cohort study
A1 Sanchez-Lastra, Miguel Adriano
A1 Ding, Ding
A1 Pozo Cruz, Borja del
A1 Dalene, Knut Eirik
A1 Ayán, Carlos
A1 Ekelund, Ulf
A1 Tarp, Jakob
A2 Didáctica de la Educación FísicaPlástica y Musical
K1 Accelerometry
K1 Exercise
K1 Sedentary Lifestyle
AB Objective To examine the joint associations between physical activity and abdominal obesity with the risk of cardiovascular disease (CVD) events. Methods We included 70 830 UK Biobank participants (mean age±SD=61.6 ± 7.9 years; 56.4% women) with physical activity measured by wrist-worn accelerometers and without major chronic diseases. Participants were jointly categorised into six groups based on their physical activity level (tertiles of total volume and specific intensity levels) and presence or absence of abdominal obesity based on measured waist circumference. Associations with incident CVD (fatal and non-fatal events) were determined using proportional subdistribution hazard models with multivariable adjustment. Results After excluding events during the first 2 years of follow-up, participants were followed for a median of 6.8 years, during which 2795 CVD events were recorded. Compared with the low abdominal adiposity and highest tertile of physical activity, abdominal obesity was associated with higher risk of incident CVD, especially in those with low levels of vigorous-intensity physical activity (HR 1.42, 95% CI 1.22 to 1.64). Approximately 500 min per week of moderate-to-vigorous intensity and approximately 30–35 min of vigorous-intensity physical activity offset the association of abdominal obesity and the risk of having a CVD event. Conclusion Physical activity equivalent to approximately 30–35 min of vigorous intensity per week appears to offset the association between abdominal obesity and incident CVD. About 15 times more physical activity of at least moderate intensity is needed to achieve similar results.
PB BMJ Publishing Group
SN 1473-0480
YR 2023
FD 2023
LK http://hdl.handle.net/10498/32297
UL http://hdl.handle.net/10498/32297
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 09-may-2026