RT journal article
T1 Physiological Mechanisms Inherent to Diabetes Involved in the Development of Dementia: Alzheimer’s Disease
A1 Mohamed Mohamed, Himan
A1 García Morales, Victoria
A1 Sánchez Lara, Encarnación María
A1 González Acedo, Anabel
A1 Pardo Moreno, Teresa
A1 Tovar Gálvez, María Isabel
A1 Melguizo-Rodríguez, Lucía
A1 Ramos-Rodríguez, Juan José
A2 BiomedicinaBiotecnología y Salud Pública
K1 Alzheimer’s disease
K1 dementia
K1 diabetes
K1 insulin
K1 neurodegeneration
K1 neuroinflammation
K1 neuron death
K1 vascular dementia
AB Type 2 diabetes mellitus (T2D) is a metabolic disease reaching pandemic levels worldwide. In parallel, Alzheimer’s disease (AD) and vascular dementia (VaD) are the two leading causes of dementia in an increasingly long-living Western society. Numerous epidemiological studies support the role of T2D as a risk factor for the development of dementia. However, few basic science studies have focused on the possible mechanisms involved in this relationship. On the other hand, this review of the literature also aims to explore the relationship between T2D, AD and VaD. The data found show that there are several alterations in the central nervous system that may be promoting the development of T2D. In addition, there are some mechanisms by which T2D may contribute to the development of neurodegenerative diseases such as AD or VaD.
PB Multidisciplinary Digital Publishing Institute (MDPI)
SN 2035-8377
YR 2023
FD 2023
LK http://hdl.handle.net/10498/32421
UL http://hdl.handle.net/10498/32421
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 08-nov-2026