RT journal article
T1 Current Treatments and New, Tentative Therapies for Parkinson’s Disease
A1 Pardo-Moreno, Teresa
A1 García Morales, Victoria
A1 Suleiman-Martos, Sami
A1 Rivas-Domínguez, Antonio
A1 Mohamed-Mohamed, Himan
A1 Ramos Rodríguez, Juan José
A1 Melguizo-Rodríguez, Lucía
A1 González-Acedo, Anabel
A2 BiomedicinaBiotecnología y Salud Pública
K1 alpha-synuclein
K1 Lewy bodies
K1 Parkinson’s disease
K1 therapeutic targets
AB Parkinson’s disease (PD) is a neurodegenerative pathology, the origin of which is associatedwith the death of neuronal cells involved in the production of dopamine. The prevalence of PD hasincreased exponentially. The aim of this review was to describe the novel treatments for PD that arecurrently under investigation and study and the possible therapeutic targets. The pathophysiologyof this disease is based on the formation of alpha-synuclein folds that generate Lewy bodies, whichare cytotoxic and reduce dopamine levels. Most pharmacological treatments for PD target alphasynucleinto reduce the symptoms. These include treatments aimed at reducing the accumulationof alpha-synuclein (epigallocatechin), reducing its clearance via immunotherapy, inhibiting LRRK2,and upregulating cerebrosidase (ambroxol). Parkinson’s disease continues to be a pathology ofunknown origin that generates a significant social cost for the patients who suffer from it. Althoughthere is still no definitive cure for this disease at present, there are numerous treatments availableaimed at reducing the symptomatology of PD in addition to other therapeutic alternatives that arestill under investigation. However, the therapeutic approach to this pathology should include acombination of pharmacological and non-pharmacological strategies to maximise outcomes andimprove symptomatological control in these patients. It is therefore necessary to delve deeper intothe pathophysiology of the disease in order to improve these treatments and therefore the quality oflife of the patients.
PB MDPI
SN 1999-4923
YR 2023
FD 2023
LK http://hdl.handle.net/10498/32443
UL http://hdl.handle.net/10498/32443
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 07-nov-2026