RT journal article
T1 Structure−Activity Relationship (SAR) Study of trans-Cinnamic Acid and Derivatives on the Parasitic Weed Cuscuta campestris
A1 Moreno-Robles, Antonio
A1 Cala Peralta, Antonio
A1 García Zorrilla, Jesús
A1 Soriano, Gabriele
A1 Masi, Marco
A1 Vilariño-Rodríguez, Susana
A1 Cimmino, Alessio
A1 Fernández-Aparicio, Mónica
A2 Química Orgánica
K1 enhanced activity
K1 field dodder
K1 growth inhibition
K1 natural compounds
K1 parasitic weeds
K1 structural analogs
K1 sustainable crop protection
AB Cuscuta campestris Yunck. is a parasitic weed responsible for severe yield losses in cropsworldwide. The selective control of this weed is scarce due to the difficult application of methods thatkill the parasite without negatively affecting the infected crop. trans-Cinnamic acid is secreted by plantroots naturally into the rhizosphere, playing allelopathic roles in plant–plant communities, althoughits activity in C. campestris has never been investigated. In the search for natural molecules with phytotoxicactivity against parasitic weeds, this work hypothesized that trans-cinnamic acid could be activein inhibiting C. campestris growth and that a study of a series of analogs could reveal key structuralfeatures for its growth inhibition activity. In the present structure–activity relationship (SAR) study,we determined in vitro the inhibitory activity of trans-cinnamic acid and 24 analogs. The resultsshowed that trans-cinnamic acid’s growth inhibition of C. campestris seedlings is enhanced in eightof its derivatives, namely hydrocinnamic acid, 3-phenylpropionaldehyde, trans-cinnamaldehyde,trans-4-(trifluoromethyl)cinnamic acid, trans-3-chlorocinnamic acid, trans-4-chlorocinnamic acid,trans-4-bromocinnamic acid, and methyl trans-cinnamate. Among the derivatives studied, the methylester derivative of trans-cinnamic acid was the most active compound. The findings of this SARstudy provide knowledge for the design of herbicidal treatments with enhanced activity againstparasitic weeds.
PB MDPI
SN 2223-7747
YR 2023
FD 2023
LK http://hdl.handle.net/10498/32444
UL http://hdl.handle.net/10498/32444
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026