RT journal article
T1 Optimization of a New Ultrasound-Assisted Extraction Method of Caffeic Acid from the Aerial Parts of Coriandrum sativum by Using Experimental Design and Ultra-Performance Liquid Chromatography
A1 Messaoudene, Lynda
A1 Palma Lovillo, Miguel
A1 Carrera Fernández, Ceferino Adrián
A1 Setyaningsih, Widiastuti
A1 Hazzit, Mohamed
A1 Djebbar, Réda
A2 Química Analítica
K1 Coriandrumsativum
K1 caffeic acid
K1 ultrasound-assisted extraction
K1 response surfacemethodology
K1 phenolic compounds
K1 Box–Behnken
AB Coriander (Coriandrum sativum L.) is among the most widely used medicinal and aromaticplants. It is well known for its multiple health benefits, most of which are correlated with its phenoliccomposition. Four phenolic compounds were identified in the extracts of aerial parts of corianderextracts, including caffeic acid, isoquercitrin, quercetin-3-O-glucuronide, and rutin. Caffeic acid wasthe major compound in the extracts. A Box–Behnken Design (BBD) was employed in conjunctionwith the response surface methodology (RSM) to develop an ultrasound-assisted extraction methodfor the determination of phenolic compounds in the aerial parts of coriander using the level of caffeicacid as the target response. The following working variables were evaluated: methanol level in theextraction solvent, temperature, sonication time, and liquid-to-solvent ratio. It was found that themethanol concentration is the most significant factor that influences the recovery of caffeic acid. Theoptimal extraction conditions were: 10 min as the extraction time, 70  C as the temperature, 50%for methanol in water as the solvent, and 6.51 mL of solvent per gram of sample. The repeatabilityand reproducibility were calculated and RSD values below 6% were obtained in both cases. Thenew method was employed for the extraction of real coriander samples and it is suggested that thismethod could potentially be applied for quality control analyses.
PB MDPI
SN 2297-8739
YR 2023
FD 2023
LK http://hdl.handle.net/10498/32474
UL http://hdl.handle.net/10498/32474
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026