RT journal article T1 Effectiveness of the Combined Use of a Brain–Machine Interface System and Virtual Reality as a Therapeutic Approach in Patients with Spinal Cord Injury: A Systematic Review A1 De Miguel-Rubio, Amaranta A1 Gallego-Aguayo, Ignacio A1 De Miguel-Rubio, María Dolores A1 Arias-Avila, Mariana A1 Lucena Antón, David Manuel A1 Alba Rueda, Alvaro A2 Enfermería y Fisioterapia K1 brain–computer interfaces K1 rehabilitation K1 spinal cord injuries K1 virtual reality AB Spinal cord injury has a major impact on both the individual and society. This damage can cause permanent loss of sensorimotor functions, leading to structural and functional changes in somatotopic regions of the spinal cord. The combined use of a brain–machine interface and virtual reality offers a therapeutic alternative to be considered in the treatment of this pathology. This systematic review aimed to evaluate the effectiveness of the combined use of virtual reality and the brain–machine interface in the treatment of spinal cord injuries. A search was performed in PubMed, Web of Science, PEDro, Cochrane Central Register of Controlled Trials, CINAHL, Scopus, and Medline, including articles published from the beginning of each database until January 2023. Articles were selected based on strict inclusion and exclusion criteria. The Cochrane Collaboration’s tool was used to assess the risk of bias and the PEDro scale and SCIRE systems were used to evaluate the methodological quality of the studies. Eleven articles were selected from a total of eighty-two. Statistically significant changes were found in the upper limb, involving improvements in shoulder and upper arm mobility, and weaker muscles were strengthened. In conclusion, most of the articles analyzed used the electroencephalogram as a measurement instrument for the assessment of various parameters, and most studies have shown improvements. Nonetheless, further research is needed with a larger sample size and long-term follow-up to establish conclusive results regarding the effect size of these interventions. PB MDPI SN 2227-9032 YR 2023 FD 2023 LK http://hdl.handle.net/10498/32661 UL http://hdl.handle.net/10498/32661 LA eng DS Repositorio Institucional de la Universidad de Cádiz RD 09-nov-2026