RT journal article
T1 Oral cortisol and dexamethasone intake: Differential physiology and transcriptional responses in the marine juvenile Sparus aurata
A1 Barany Ruiz, Andre
A1 Fuentes, J.
A1 Valderrama, V.
A1 Broz Ruiz, Álvaro
A1 Martínez-Rodríguez, Gonzalo
A1 Mancera Romero, Juan Miguel
A2 Biología
K1 Glucocorticoids
K1 Intestine
K1 Metabolism
K1 Osmoregulation
K1 Ussing chamber
AB This study approached the long-term oral administration of cortisol (F) and dexamethasone (DEX), two synthetic glucocorticoids, compared to a control group (CT) in the juveniles of a marine teleost, the gilthead seabream (Sparus aurata). Physiologically, DEX treatment impaired growth, which appears to be linked to carbohydrate allocation in muscle and liver, hepatic triglycerides depletion, and reduced hematocrit. Hypophyseal gh mRNA expression was 2-fold higher in DEX than in CT or F groups. Similarly, hypothalamic trh and hypophyseal pomcb followed this pattern. Plasma cortisol levels were significantly lower in DEX than in CT, while F presented intermediate levels. In the posterior intestine, measured short circuit-current (Isc) was more anion absorptive in CT and F compared to the DEX group, whereas Isc remained unaffected in the anterior intestine. The derived transepithelial electric resistance (TEER) significantly differed between intestinal regions in the DEX group. These results provide new insights to understand better potential targeted biomarkers indicative of the differential glucocorticoid or mineralocorticoid-receptors activation in fish.
PB Academic Press Inc.
SN 1095-6840
YR 2023
FD 2023
LK http://hdl.handle.net/10498/32669
UL http://hdl.handle.net/10498/32669
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 21-sep-2026