RT journal article
T1 Suppressive Activity of Glechoma hederacea Extracts against the Phytopathogenic Oomycete Plasmopara viticola, and First Screening of the Active Metabolites
A1 García Zorrilla, Jesús
A1 Giovannini, O.
A1 Nadalini, S.
A1 Zanini, A.
A1 Russo, Maria Teresa
A1 Masi, Marco
A1 Puopolo, G.
A1 Cimmino, Alessio
A2 Química Orgánica
K1 Glechoma hederacea
K1 Plasmopora viticola
K1 allelopathy
K1 plant extracts
K1 caffeic acid
K1 methyl caffeate
AB Plasmopara viticola is a destructive oomycete that affects grapevines, causing significant economic losses worldwide. This study highlights how the plant Glechoma hederacea might be at the basis for the development of biofungicides to control P. viticola. The aqueous extract obtained from G. hederacea aerial parts showed strong inhibition activity against P. viticola, comparable to that of copper hydroxide. The bioguided purification of the extract by chromatographic techniques led to the isolation of six pure metabolites, identified as the aromatic compounds carvacrol, caffeic acid and methyl caffeate, the flavonoids cirsimaritin and apigenin and the polyphenolic acid rosmarinic acid by spectroscopic methods. This is the first report about the isolation of methyl caffeate and cirsimaritin from G. hederacea. Caffeic acid and methyl caffeate showed the highest disease severity reduction, while carvacrol, cirsimaritin and apigenin also showed moderate activity against P. viticola. The inhibitory activity of the aqueous extract could suggest synergetic or additive action of caffeic acid and methyl caffeate together with other compounds contained in the extract. This study provides insights into the potential of G. hederacea as an allelopathic tool for developing control methods against P. viticola, revealing the combined action of different metabolites involved in the mechanism of action of the active compounds.
PB MDPI
SN 2077-0472
YR 2024
FD 2024
LK http://hdl.handle.net/10498/32707
UL http://hdl.handle.net/10498/32707
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026