RT journal article
T1 Sesquiterpene Lactones Isolated from Centaurea cineraria L. subsp. cineraria Inhibit the Radicle Growth of Broomrape Weeds
A1 García Zorrilla, Jesús
A1 Innangi, M.
A1 Cala Peralta, Antonio
A1 Soriano, Gabriele
A1 Russo, Maria Teresa
A1 Masi, Marco
A1 Fernández-Aparicio, Mónica
A1 Cimmino, Alessio
A2 Química Orgánica
K1 parasitic weeds
K1 Orobanche
K1 Phelipanche
K1 allelochemicals
K1 cnicin
K1 sesquiterpene lactones
K1 sustainable crop protection
AB The plant Centaurea cineraria L. subsp. cineraria has been investigated as a potential source of inhibitors of broomrape radicle growth. The latter are weeds that pose a threat to agriculture and for which there are few methods available for the control of infestations. Four sesquiterpene lactones have been isolated from C. cineraria L. subsp. cineraria aerial parts and identified as isocnicin, cnicin, salonitenolide, and 11β,13-dihydrosalonitenolide using spectroscopic, spectrometric, and optical methods. Salonitenolide and 11β,13-dihydrosalonitenolide have been isolated for the first time from this plant. Tested at 1.0–0.1 mM against the broomrape species Phelipanche ramosa, Orobanche minor, Orobanche crenata, and Orobanche cumana, isocnicin, cnicin, and salonitenolide demonstrated remarkable inhibitory activity (over 80% in most of the cases) at the highest concentrations. Structure-activity relationship conclusions indicated the significance of the α,β-unsaturated lactone ring. In addition, the synthetic acetylated derivative of salonitenolide showed the strongest activity among all compounds tested, with inhibitions close to 100% at different concentrations, which has been related to a different lipophilicity and the absence of H-bond donor atoms in its structure. Neither the extracts nor the compounds exhibited the stimulating activity of broomrape germination (induction of suicidal germination). These findings highlight the potential of C. cineraria to produce bioactive compounds for managing parasitic weeds and prompt further studies on its sesquiterpene lactones as tools in developing natural product-based herbicides.
PB MDPI
SN 2223-7747
YR 2024
FD 2024
LK http://hdl.handle.net/10498/32709
UL http://hdl.handle.net/10498/32709
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 08-nov-2026