RT journal article
T1 Gonadotropin-inhibitory hormone and its receptors in teleosts: Physiological roles and mechanisms of actions
A1 Wang, B.
A1 Paullada Salmerón, José Antonio
A1 Muñoz Cueto, José Antonio
A2 Biología
K1 GnIH
K1 NPFF
K1 GnRH
K1 Kisspeptin
K1 GnIH receptor
K1 Reproduction
K1 Signaling pathway
AB Gonadotropin-inhibitory hormone (GnIH) was the first reported hypothalamic neuropeptide inhibiting reproduction in vertebrates. Since its discovery in the quail brain, its orthologs have been identified in a variety ofvertebrate species and even protochordates. Depending on the species, the GnIH precursor polypeptides comprisetwo, three or four mature peptides of the RFamide family. It has been well documented that GnIH inhibitsreproduction at the brain-pituitary–gonadal levels and participates in metabolism, stress response, and socialbehaviors in birds and mammals. However, most studies in fish have mainly been focused on the physiologicalroles of GnIH in the control of reproduction and results obtained are in some cases conflicting, leaving aside itspotential roles in the regulation of other functions. In this manuscript we summarize the information available infish with respect to the structural diversity of GnIH peptides and functional roles of GnIH in reproduction andother physiological processes. We also highlight the molecular mechanisms of GnIH actions on target cells andpossible interactions with other neuroendocrine factors.
SN 1095-6840
YR 2024
FD 2024-02-20
LK http://hdl.handle.net/10498/32737
UL http://hdl.handle.net/10498/32737
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 07-nov-2026