RT journal article
T1 Corpus callosum long-term biometry in very preterm children related to cognitive and motor outcomes
A1 Lubián Gutiérrez, Manuel
A1 Benavente Fernández, Isabel
A1 Marín-Almagro, Y.
A1 Jiménez Luque, Natalia
A1 Zuazo Ojeda, Mirem Amaya
A1 Sánchez Sandoval, Yolanda
A1 Lubián López, Simón Pedro
A2 Materno-Infantil y Radiología
A2 Psicología
AB BACKGROUND: The corpus callosum (CC) is suggested as an indirect biomarker of white matter volume, which is often affected inpreterm birth. However, diagnosing mild white matter injury is challenging.METHODS: We studied 124 children born preterm (mean age: 8.4 ± 1.1 years), using MRI to assess CC measurements and cognitive/motor outcomes based on the Wechsler Intelligence Scale for Children-V (WPPSI-V) and Movement Assessment Battery forChildren-2 (MABC-2).RESULTS: Children with normal outcomes exhibited greater height (10.2 ± 2.1 mm vs. 9.4 ± 2.3 mm; p = 0.01) and fractionalanisotropy at splenium (895[680–1000] vs 860.5[342–1000]) and total CC length (69.1 ± 4.8 mm vs. 67.3 ± 5.1 mm; p = 0.02)compared to those with adverse outcomes. All measured CC areas were smaller in the adverse outcome group. Modelsincorporating posterior CC measurements demonstrated the highest specificity (83.3% Sp, AUC: 0.65) for predicting neurologicaloutcomes. CC length and splenium height were the only linear measurements associated with manual dexterity and total MABC-2score while both the latter and genu were related with Full-Scale Intelligence Quotient.CONCLUSIONS: CC biometry in children born very preterm at school-age is associated with outcomes and exhibits a specificsubregion alteration pattern. The posterior CC may serve as an important neurodevelopmental biomarker in very preterm infants.
PB Springer Nature
SN 1530-0447
YR 2024
FD 2024
LK http://hdl.handle.net/10498/32760
UL http://hdl.handle.net/10498/32760
LA eng
NO Ministerio de Ciencia, Innovación y Universidades (España)European Commission (Unión Europea)Instituto de Salud Carlos III (España)Fondos europeos de desarrollo regional (Unión Europea)
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026