RT journal article
T1 Physical activity, chronic kidney disease, and cardiovascular risk: A study in half a million adults
A1 Castillo-García, A.
A1 Valenzuela, P.L.
A1 Saco-Ledo, G.
A1 Morales Rojas, Javier Salvador
A1 Ruilope, L.M.
A1 Santos-Lozano, A.
A1 Lucia, A.
A2 Didáctica de la Educación FísicaPlástica y Musical
K1 CVD risk factors
K1 Glomerular filtration rate
K1 Kidney function
K1 Physical inactivity
AB Objective: There is a growing prevalence of chronic kidney disease (CKD), a con-dition associated with a higher cardiovascular disease (CVD) risk. We assessedthe association between self-reported physical activity (PA) and CKD and alsostudied whether PA attenuates CKD-associated CVD risk.Methods: A cohort of Spanish adults (18–64 years) participated in this nation-wide study. Participants were categorized at baseline as being either inactive (per-forming no PA), regularly, or insufficiently active (meeting or not, respectively,international PA recommendations) and were followed for up to 5 years. Thepresence of CKD (estimated glomerular filtration rate <60 mL/min/1.73 m2) andmajor CVD risk factors (diabetes, hypercholesterolemia, hypertension, obesity)was determined at baseline and at follow- up.Results: 517 917 participants (44 ± 9 years, 67% male, CKD prevalence = 7%)were studied at baseline, with prospective analyses (median follow-up = 2 years,range = 2–5) in a subcohort of 264 581 individuals. Compared to physical inactiv-ity, cross-sectional analyses at baseline showed that regular PA (odds ratio = 0.80;95% confidence interval = 0.79–0.81), but not insufficient PA (1.02; 0.99–1.04) wasassociated with lower CKD prevalence. However, prospective analyses failed toconfirm this association (p > 0.1). In turn, CKD was associated with a higher prev-alence of hypertension (+3%) and diabetes (+5%) at baseline and with a greaterincidence of hypertension at follow-up (+37%). Among those participants withCKD, regular PA was associated with a lower prevalence (−45% to −7%) and in-cidence (−38% to −4%) of all CVD risk factors.Conclusion: Although PA might not reduce incident CKD in the middle term(~2 years), it can attenuate the CVD risk linked to this condition.
PB John Wiley and Sons
SN 1600-0838
YR 2024
FD 2024
LK http://hdl.handle.net/10498/32766
UL http://hdl.handle.net/10498/32766
LA eng
NO Federación Española de Enfermedades Raras (España) Ministerio de Economía y Competitividad (España) Instituto de Salud Carlos III (España)
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026