RT journal article
T1 Exploring the Intricacies of Neurogenic Niches: Unraveling the Anatomy and Neural Microenvironments
A1 Sánchez Gomar, Ismael
A1 Geribaldi Doldán, Noelia
A1 Santos Rosendo, Celeste
A1 Sanguino-Caneva, C.
A1 Carrillo-Chapman, C.
A1 Fiorillo Moreno, Ornella
A1 Villareal Camacho, J.L.
A1 Navarro Quiroz, Elkin
A1 Verástegui Escolano, Cristina
A2 Anatomía y Embriología Humana
A2 Biología
A2 BiomedicinaBiotecnología y Salud Pública
K1 anatomy
K1 nervous system
K1 neurogenic niches
K1 neural stem cells
K1 adult neurogenesis
AB Neurogenesis is the process of forming new neurons from neural stem cells (NSCs). In adults, this process takes place in specific areas of the brain, known as neurogenic niches. These regions have unique anatomical features that have been studied in animal models and in the human brain; however, there are differences between these models that need to be addressed. The most studied areas are the subventricular zone, the lateral and latero-dorsal walls of the lateral ventricles, and the dentate gyrus of the hippocampus (Hp), which are known as the canonical areas. Other, less-studied niches, such as the hypothalamus, the cerebellum, and the amygdala, are known as non-canonical areas. Anatomy occupies a relevant place in adult neurogenesis, in which the tissue architecture and cellular location are necessities for the interaction and release of diverse molecules that allow this phenomenon. The cell arrangement within the niche and the location of the niche itself are of particular relevance to the state in which the NSCs are found. Consequently, the majority of previous discoveries have been related to pathology. While many studies are based on animal models, discoveries related to neurogenesis in humans have also been made; however, in this case, opinions vary, leading to extensive controversy in recent years. In this review, we address the anatomical characteristics of the different brain regions to better understand their relationships within neurogenesis.
PB MDPI
SN 2218-273X
YR 2024
FD 2024-03-12
LK http://hdl.handle.net/10498/32864
UL http://hdl.handle.net/10498/32864
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 07-nov-2026