RT journal article
T1 Enhancing Structural Diversity of Lathyrane Derivatives through Biotransformation by the Marine-Derived Actinomycete Streptomyces puniceus BC-5GB.11
A1 Escobar Montaño, Felipe
A1 González Rodríguez, Victoria Eugenia
A1 Macías Sánchez, Antonio José
A1 Botubol Ares, José Manuel
A1 Durán Patrón, Rosa María
A1 Hernández Galán, Rosario
A2 BiomedicinaBiotecnología y Salud Pública
A2 Química Orgánica
K1 marine-derived actynomicete
K1 Streptomyces
K1 diterpenoids
K1 lathyranes
K1 biotransformation
AB Lathyrane-type diterpenes have a wide range of biological activities. Among them, euphoboetiraneA (1) exerts neurogenesis-promoting activity. In order to increase the structural diversityof this type of lathyrane and explore its potential use in neurodegenerative disorders, the biotransformationof 1 by Streptomyces puniceus BC-5GB.11 has been investigated. The strain BC-5GB.11, isolatedfrom surface sediments collected from the intertidal zone of the inner Bay of Cadiz, was identified asStreptomyces puniceus, as determined by phylogenetic analysis using 16S rRNA gene sequence. Biotransformationof 1 by BC-5GB.11 afforded five products (3–7), all of which were reported here for thefirst time. The main biotransformation pathways involved regioselective oxidation at non-activatedcarbons (3–5) and isomerization of the D12,13 double bond (6). In addition, a cyclopropane-rearrangedcompound was found (7). The structures of all compounds were elucidated on the basis of extensiveNMR and HRESIMS spectroscopic studies.
PB MDPI
SN 1422-0067
YR 2024
FD 2024
LK http://hdl.handle.net/10498/32867
UL http://hdl.handle.net/10498/32867
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 06-nov-2026