RT journal article
T1 Revealing Hidden Genes in Botrytis cinerea: New Insights into Genes Involved in the Biosynthesis of Secondary Metabolites
A1 Suárez Cáceres, Ivonne Rocío
A1 González Collado, Isidro
A1 Garrido Crespo, Carlos
A2 BiomedicinaBiotecnología y Salud Pública
A2 Química Orgánica
K1 Botrytis cinerea
K1 secondary metabolism
K1 polyketide synthase
K1 non-ribosomal peptide synthetase
K1 sesquiterpene cyclase
K1 diterpene cyclase
K1 dimethylallyltryptophan synthase
K1 bioinformatics
K1 fungal pathogenicity
K1 antifungal targets
AB Utilizing bioinformatics tools, this study expands our understanding of secondarymetabolism in Botrytis cinerea, identifying novel genes within polyketide synthase (PKS), nonribosomalpeptide synthetase (NRPS), sesquiterpene cyclase (STC), diterpene cyclase (DTC), anddimethylallyltryptophan synthase (DMATS) families. These findings enrich the genetic frameworkassociated with B. cinerea’s pathogenicity and ecological adaptation, offering insights into unchartedmetabolic pathways. Significantly, the discovery of previously unannotated genes provides newmolecular targets for developing targeted antifungal strategies, promising to enhance crop protectionand advance our understanding of fungal biochemistry. This research not only broadens thescope of known secondary metabolites but also opens avenues for future exploration into B. cinerea’sbiosynthetic capabilities, potentially leading to novel antifungal compounds. Our work underscoresthe importance of integrating bioinformatics and genomics for fungal research, paving the way forsustainable agricultural practices by pinpointing precise molecular interventions against B. cinerea.This study sets a foundation for further investigations into the fungus’s secondary metabolism, withimplications for biotechnology and crop disease management.
PB MDPI
YR 2024
FD 2024-05-28
LK http://hdl.handle.net/10498/33247
UL http://hdl.handle.net/10498/33247
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026