RT journal article
T1 Biomarker responses of Cu-induced toxicity in European seabass Dicentrarchus labrax: assessing oxidative stress and histopathological alterations
A1 Díaz de Alba, Margarita Isabel
A1 Canalejo Raya, Antonio
A1 Granado Castro, María Dolores
A1 Oliva Ramírez, Milagrosa
A1 El Mai, Bahija
A1 Córdoba García, Francisco
A1 Troyano Montoro, Miriam
A1 Espada Bellido, Estrella
A1 Torronteras Santiago, Rafael
A1 Galindo Riaño, María Dolores
A2 Química Analítica
K1 Biomarkers
K1 Copper
K1 Dicentrarchus labrax
K1 Oxidative stress
K1 Histopathological alterations
AB A comprehensive approach to chemical accumulation and biological effects of short-term Cu exposure in juveniles of European seabass (Dicentrarchus labrax) has been achieved. Fish were exposed to 0.01–10 mg L− 1 nominal Cu concentrations for 24–96 h. Metal concentrations in water and gills, liver, muscle and brain tissues were studied along with oxidative stress biomarkers (superoxide dismutase, catalase, glutathione peroxidase, lipid peroxidation). Induction of oxidative damage was observed in all the organs with differential antioxidant responses; gills appearing as the most sensitive from low environmentally water Cu concentrations as 0.01 mg L− 1. Histopathological alterations were also observed in liver and gills, even without a significant Cu accumulation.The results show that the combination of oxidative stress parameters, particularly lipid peroxidation and glutathione peroxidase activities, and histopathological alterations provide a good model fish and reliable early biomarkers for monitoring Cu pollution in seawater and might call for the protection agencies to revise the Cu environmental standards.
PB Elsevier
SN 0025-326X
YR 2017
FD 2017
LK http://hdl.handle.net/10498/33273
UL http://hdl.handle.net/10498/33273
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 07-nov-2026