RT journal article
T1 Noradrenergic Locus Coeruleus pathways in pain modulation.
A1 Llorca Torralba, Meritxell
A1 Borges, Gisela
A1 Neto, Fani L.
A1 Micó Segura, Juan Antonio
A1 Berrocoso Domínguez, Esther María
A2 Neurociencias
A2 Psicología
K1 Locus Coeruleus
K1 noradrenaline
K1 norepinephrine
K1 pain
K1 neuropathic pain
K1 inflammatory pain
AB The noradrenergic system is crucial for several activities in the body, including the modulation of pain. As the major producer of noradrenaline (NA) in the central nervous system (CNS), the Locus Coeruleus (LC) is a nucleus that has been studied in several pain conditions, mostly due to its strategic location. Indeed, apart from a well-known descending LC-spinal pathway that is important for pain control, an ascending pathway passing through this nucleus may be responsible for the noradrenergic inputs to higher centers of the pain processing, such as the limbic system and frontal cortices. Thus, the noradrenergic system appears to modulate different components of the pain experience and accordingly, its manipulation has distinct behavioral outcomes. The main goal of this review is to bring together the data available regarding the noradrenergic system in relation to pain, particularly focusing on the ascending and descending LC projections in different conditions. How such findings influence our understanding of these conditions is also discussed.
PB Elsevier
SN 1873-7544
YR 2016
FD 2016-12-03
LK http://hdl.handle.net/10498/33330
UL http://hdl.handle.net/10498/33330
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-may-2026