RT journal article
T1 Deep brain stimulation electrode insertion and depression: Patterns of activity and modulation by analgesics
A1 Perez-Caballero, Laura
A1 Soto-Montenegro, María Luisa
A1 Hidalgo Figueroa, María
A1 Micó Segura, Juan Antonio
A1 Berrocoso Domínguez, Esther María
A2 Psicología
K1 Deep brain stimulation
K1 Depression
K1 Anti-inflammatory/analgesic drugs
K1 Tramadol
K1 GFAP
K1 p11 protein
AB Background: An initial antidepressant effect when using deep brain stimulation (DBS) of the subcallosalarea of the cingulate cortex (Cg25) to treat resistant depression that could be the result ofelectrode insertion has been described. We previously showed that electrode insertion into theinfralimbic cortex (ILC; the Cg25 rodent correlate) provokes a temporally limited antidepressant-likeeffect that is counteracted by non-steroidal anti-inflammatory drugs, such as those routinely usedfor pain relief.Objective: We characterized the effect of electrode insertion using functional neuroimaging and evaluated the impact of different analgesics on this effect.Methods: The effect of electrode insertion into the ILC was evaluated by positron emission tomography.The effect of analgesics (ibuprofen, tramadol and morphine) on the behavioral effect inducedby electrode insertion were evaluated through the forced swimming test and the novelty suppressedfeeding test. Furthermore, glial fibrillary acidic protein (GFAP) and p11 expression were measured.Results: Electrode implantation produces an antidepressant- and anxiolytic-like effect, a local decrease in glucose metabolism, and changes in several brain regions commonly related to depression and the antidepressant response. Ibuprofen counteracted the behavioral and molecular changes produced byelectrode insertion (changes in GFAP and p11 protein expression). However, analgesics with no antiinflammatory properties (e.g., tramadol) neither counteract the behavioral effects of electrode implantation nor the molecular mechanisms triggered.Conclusions: Analgesics without anti-inflammatory properties may not limit the transient benefit produced by electrode insertion reducing the time required to achieve remission in depressive DBS patients.
PB Elsevier
SN 1876-4754
YR 2018
FD 2018-07-09
LK http://hdl.handle.net/10498/33362
UL http://hdl.handle.net/10498/33362
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-may-2026