RT journal article
T1 Provitamin Supramolecular Polymer Micelle with pH Responsiveness to Control Release, Bioavailability Enhancement and Potentiation of Cytotoxic Efficacy
A1 Rodríguez Mejías, Francisco Javier
A1 Gutiérrez Vázquez, María Teresa
A1 García Durán, Alexandra
A1 González Molinillo, José María
A1 Martínez Valdivia, Manuel Jesús
A1 Macías Domínguez, Francisco Antonio
A2 BiomedicinaBiotecnología y Salud Pública
A2 Química Orgánica
K1 Supramolecular polymer micelle
K1 Core/shell nanoparticles
K1 Encapsulation
K1 Cytotoxicity
K1 bioassay
K1 β-Carotene
AB Encapsulation techniques to generate core/shell systems provide a method that improves physicochemical properties, which are very important in biological applications. β-carotene is a common carotenoid that has shown preventive effects in skin diseases and vitamin A deficiency but this compound has limited water solubility and bioavailability, which hinder its broad application. The use of polyrotaxane compounds formed from cyclodextrins has allowed supramolecular polymer micelles (SMPMs) to be synthesized to encapsulate β-carotene. The polymeric compound Pluronic F127® was also used to create core/shell nanoparticles (NPs) that contain β-carotene. Bioactive compound encapsulation was fully confirmed by nuclear magnetic resonance spectroscopy and by scanning and transmission electron microscopy. The method based on cyclodextrin and lecithin allow to release slowly when the systems were exposed to an aqueous medium by pH control, with an increase of 16 times of bioavailability comparing with free carotenoid. This allowed to potentiate the cytotoxic activity on a melanoma cell line by enhancing the water solubility to more than 28 mg/L, and present promising applications of SMPMs to provitamins.
SN 1873-4367
YR 2019
FD 2019
LK http://hdl.handle.net/10498/33420
UL http://hdl.handle.net/10498/33420
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026