RT journal article
T1 Complexation of sesquiterpene lactones with cyclodextrins: synthesis and effects on their activities on parasitic weeds
A1 Cala Peralta, Antonio
A1 González Molinillo, José María
A1 Fernández-Aparicio, Mónica
A1 Ayuso Vilacides, Jesús
A1 Álvarez Saura, José Ángel
A1 Rubiales Olmedo, Diego
A1 Macías Domínguez, Francisco Antonio
A2 Química Orgánica
K1 deydrocostuslactone
K1 costunolide
K1 santonin
K1 cyclodextrin
K1 parasitic weed
K1 Orobanche
K1 Phelipanche
AB Allelochemicals are safer, more selective and more active alternatives than synthetic agrochemicals for weed control. However, the low solubility of these compounds in aqueous media limits their use as agrochemicals. Herein, we propose the application of α-, β- and γ-cyclodextrins to improve the physicochemical properties and biological activities of three sesquiterpene lactones: dehydrocostuslactone, costunolide and (−)-α-santonin. Complexation was achieved by kneading and coprecipitation methods. Aqueous solubility was increased in the range 100–4600% and the solubility–phase diagrams suggested that complex formation had been successful. The results of the PM3 semiempirical calculations were consistent with the experimental results. The activities on etiolated wheat coleoptiles, Standard Target Species and parasitic weeds were improved. Cyclodextrins preserved or enhanced the activity of the three sesquiterpene lactones. Free cyclodextrins did not show significant activity and therefore the enhancement in activity was due to complexation. These results are promising for applications in agrochemical design.
PB Royal Society of Chemistry
SN 1477-0539
YR 2017
FD 2017-07-19
LK http://hdl.handle.net/10498/33422
UL http://hdl.handle.net/10498/33422
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 08-nov-2026