RT journal article
T1 Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
A1 Zeisel, A.
A1 Muñoz Manchado, Ana Belén
A1 Codeluppi, S.
A1 Lönnerberg, P.
A1 Manno, Giorgio
A1 Juréus, A.
A1 Marques, S.
A1 Munguba, H.
A1 He, L.
A1 Betsholtz, C.
A1 Rolny, C.
A1 Castelo-Branco, G.
A1 Hjerling-Leffler, Jens
A1 Linnarsson, S.
A2 Anatomía PatológicaBiología Celular, Histología, Historia de la Ciencia, Medicina Legal y Forense y Toxicología
AB The mammalian cerebral cortex supports cognitive functions such as sensorimotor integration, memory, and social behaviors. Normal brain function relies on a diverse set of differentiated cell types, including neurons, glia, and vasculature. Here, we have used large-scale single-cell RNA sequencing (RNA-seq) to classify cells in the mouse somatosensory cortex and hippocampal CA1 region. We found 47 molecularly distinct subclasses, comprising all known major cell types in the cortex. We identified numerous marker genes, which allowed alignment with known cell types, morphology, and location. We found a layer I interneuron expressing Pax6 and a distinct postmitotic oligodendrocyte subclass marked by Itpr2. Across the diversity of cortical cell types, transcription factors formed a complex, layered regulatory code, suggesting a mechanism for the maintenance of adult cell type identity.
PB American Association for the Advancement of Science
SN 1095-9203
YR 2015
FD 2015
LK http://hdl.handle.net/10498/33431
UL http://hdl.handle.net/10498/33431
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 13-nov-2026