RT journal article
T1 Neuroprotective and reparative effects of carotid body grafts in a chronic MPTP model of Parkinson’s disease
A1 Muñoz Manchado, Ana Belén
A1 Villadiego, Javier
A1 Suárez Luna, Nela
A1 Bermejo-Navas, A.
A1 Garrido-Gil, P.
A1 Labandeira-García, J.L.
A1 Echevarría, M.
A1 López Barneo, José
A1 Toledo Aral, Juan J.
A2 Anatomía PatológicaBiología Celular, Histología, Historia de la Ciencia, Medicina Legal y Forense y Toxicología
AB Intrastriatal transplantation of dopaminergic carotid body (CB) cells ameliorates parkinsonism in animal models and, with less efficacy, in Parkinson’s disease patients. CB-based cell therapy was initially proposed because of its high dopamine content. However, later studies suggested that its beneficial effect might be due to a trophic action exerted on nigrostriatal neurons. Compatible with this concept are the high levels of neurotrophic factors encountered in CB cells. To test experimentally this idea, unilateral striatal transplants were performed with a sham graft in the contralateral striatum, as a robust internal control. Thereafter, the dopaminergic neurotoxin 1-methyl-4-phenyl- 1,2,3,6, -tetrahydropyridine was injected during 3 months. CB grafts protected from degeneration ipsilateral nigral dopaminergic neurons projecting to the transplant in a dose-dependent manner regarding size and glial cell line-derived neurotrophic factor expression. Grafts performed at different times after the onset of the neurotoxic treatment demonstrated with histological and behavioral methods protection and repair of the nigrostriatal pathway by CB transplants. This study provides a mechanistic explanation for the action of CB transplants on parkinsonian models. It should also help to improve cell therapy approaches to Parkinson’s disease.
PB Elsevier
SN 0197-4580
YR 2013
FD 2013
LK http://hdl.handle.net/10498/33470
UL http://hdl.handle.net/10498/33470
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026