RT journal article
T1 Discovery of new eremophilanes from the marine-derived fungus Emericellopsis maritima BC17 by culture conditions changes: evaluation of cytotoxic and antimicrobial activities
A1 Roca Virués de Segovia, Jorge
A1 Pinedo Rivilla, Cristina
A1 Zorrilla Cuenca, David
A1 Sánchez Márquez, Jesús
A1 Sánchez, Pilar
A1 Ramos, María C.
A1 de la Cruz, Mercedes
A1 Aleu Casatejada, Josefina
A1 Durán Patrón, Rosa María
A2 Química Física
A2 Química Orgánica
K1 antimicrobial
K1 antitumoral
K1 Emericellopsis maritima
K1 eremophilane
K1 marine-derived fungus
K1 OSMAC approach
AB In our previous studies, the marine-derived fungus Emericellopsis maritima BC17 was found to produce new eremophilane-type sesquiterpenoids on solid media. In order to explore its potential to produce more metabolites, E. maritima BC17 was subjected to a one strain-many compounds (OSMAC) analysis leading to the discovery of three new eremophilanes (1-3) and fourteen known derivatives (4-17) in the liquid media Czapek Dox and PDB. Their structures were established by extensive analyses of the 1D and 2D NMR, and HRESIMS data, as well as ECD data for the assignment of their absolute configurations. Antitumoral and antimicrobial activities of the isolated metabolites 1, 3, 11, and 15 were investigated. PR toxin 3-deacetyl (15) exhibited cytotoxic activity against HepG2, MCF-7, A549, A2058 and Mia PaCa-2 human cancer cell lines with IC50 values ranging from 2.5 to 14.7 µM. In addition, 15 exhibited selective activity against methicillin-sensitive Staphylococcus aureus ATCC29213 at the highest concentration tested of 128 µg/mL.
PB Frontiers Media SA
SN 2296-7745
YR 2024
FD 2024
LK http://hdl.handle.net/10498/33510
UL http://hdl.handle.net/10498/33510
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 06-nov-2026