RT journal article
T1 Cografting of carotid body cells improves the long-term survival, fiber outgrowth and functional effects of grafted dopaminergic neurons
A1 Rodriguez-Pallares, J.
A1 Joglar, B.
A1 Muñoz Manchado, Ana Belén
A1 Villadiego, J.
A1 Toledo Aral, Juan J.
A1 Labandeira-García, J.L.
A2 Anatomía PatológicaBiología Celular, Histología, Historia de la Ciencia, Medicina Legal y Forense y Toxicología
K1 carotid body
K1 cell therapy
K1 dopamine
K1 GDNF
K1 neuroprotection
K1 Parkinson rat transplantation
AB Aims: A major limiting factor for cell therapy in Parkinson's disease is that the survival of grafted dopaminergic neurons is very poor, which may be improved by administration of GDNF, for which the carotid body is a good source.Materials & methods: Rats with total unilateral dopaminergic denervation were grafted with a cell suspension of rat dopaminergic neuroblasts with or without cell aggregates from the rat carotid body. At 1, 2 and 3 months after grafting, the rats were tested in the cylinder and the rotometer and killed 4 months after grafting.Results: We observed that the survival of dopaminergic neurons and graft-derived dopaminergic innervation were higher in rats that received mixed grafts. Both grafted groups showed complete recovery in the amphetamine-induced rotation test. However, rats with cografts performed significantly better in the cylinder test.Conclusion: Cografting of carotid body cells may constitute a useful strategy for cell therapy in Parkinson's disease.
SN 1746-076X
YR 2012
FD 2012
LK http://hdl.handle.net/10498/33512
UL http://hdl.handle.net/10498/33512
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026