RT journal article
T1 A systematic review of the biomarkers associated with cognition and mood state in bipolar disorder
A1 Pérez-Ramos, A.
A1 Romero López Alberca, Cristina
A1 Hidalgo Figueroa, María
A1 Berrocoso Domínguez, Esther María
A1 Pérez Revuelta, José Ildefonso
A2 Psicología
K1 Biomarker
K1 Bipolar disorder
K1 Cognition
K1 Mood state
K1 Psychiatry
AB Background Bipolar disorder (BD) is a severe psychiatric disorder characterized by changes in mood that alternatebetween (hypo) mania or depression and mixed states, often associated with functional impairment and cognitivedysfunction. But little is known about biomarkers that contribute to the development and sustainment of cognitivedefcits. The aim of this study was to review the association between neurocognition and biomarkers across diferentmood states.Method Search databases were Web of Science, Scopus and PubMed. A systematic review was carried out fol‑lowing the PRISMA guidelines. Risk of bias was assessed with the Newcastle–Ottawa Scale. Studies were selectedthat focused on the correlation between neuroimaging, physiological, genetic or peripheral biomarkers and cog‑nition in at least two phases of BD: depression, (hypo)mania, euthymia or mixed. PROSPERO Registration No.:CRD42023410782.Results A total of 1824 references were screened, identifying 1023 published articles, of which 336 were consideredeligible. Only 16 provided information on the association between biomarkers and cognition in the diferent afectivestates of BD. The included studies found: (i) Diferences in levels of total cholesterol and C reactive protein dependingon mood state; (ii) There is no association found between cognition and peripheral biomarkers; (iii) Neuroimagingbiomarkers highlighted hypoactivation of frontal areas as distinctive of acute state of BD; (iv) A deactivation failurehas been reported in the ventromedial prefrontal cortex (vmPFC), potentially serving as a trait marker of BD.Conclusion Only a few recent articles have investigated biomarker-cognition associations in BD mood phases.Our fndings underline that there appear to be central regions involved in BD that are observed in all mood states.However, there appear to be underlying mechanisms of cognitive dysfunction that may vary across diferent moodstates in BD. This review highlights the importance of standardizing the data and the assessment of cognition, as wellas the need for biomarkers to help prevent acute symptomatic phases of the disease, and the associated functionaland cognitive impairment.
PB Springer
SN 2194-7511
YR 2024
FD 2024
LK http://hdl.handle.net/10498/33591
UL http://hdl.handle.net/10498/33591
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 09-nov-2026