RT journal article
T1 Differences in clinical outcomes of bloodstream infections caused by Klebsiella aerogenes, Klebsiella pneumoniae and Enterobacter cloacae: a multicentre cohort study
A1 Guedes, Mariana
A1 Gathara, David
A1 López Hernández, Inmaculada
A1 Martínez Pérez-Crespo, Pedro María
A1 Pérez Rodríguez, María Teresa
A1 Sousa, Adrian
A1 Plata, Antonio
A1 Reguera Iglesias, José María
A1 Boix Palop, Lucía
A1 Dietl, Beatriz
A1 Blanco, Juan Sevilla
A1 Castillo, Carlos Armiñanzas
A1 Galán Sanchez, Fátima
A1 Kindelán, Clara Natera
A1 Jóver Saenz, Alfredo
A1 Aguirre, Josune Goikoetxea
A1 Alemán, Ana Alemán
A1 Marrodán Ciordia, Teresa
A1 del Arco Jiménez, Alfonso
A1 Fernández Suárez, Jonathan
A1 López Cortés, Luis Eduardo
A1 Rodríguez Baño, Jesús
A2 BiomedicinaBiotecnología y Salud Pública
K1 Bloodstream infection
K1 Enterobacter cloacae
K1 Klebsiella aerogenes
K1 Klebsiella pneumoniae
K1 Mortality
K1 Recurrence
AB Background: Klebsiella aerogenes has been reclassified from Enterobacter to Klebsiella genus due to its phenotypic and genotypic similarities with Klebsiella pneumoniae. It is unclear if clinical outcomes are also more similar. This study aims to assess clinical outcomes of bloodstreams infections (BSI) caused by K. aerogenes, K. pneumoniae and Enterobacter cloacae, through secondary data analysis, nested in PRO-BAC cohort study. Methods: Hospitalized patients between October 2016 and March 2017 with monomicrobial BSI due to K. aerogenes, K. pneumoniae or E. cloacae were included. Primary outcome was a composite clinical outcome including all-cause mortality or recurrence until 30 days follow-up. Secondary outcomes were fever ≥ 72 h, persistent bacteraemia, and secondary device infection. Multilevel mixed-effect Poisson regression was used to estimate the association between microorganisms and outcome. Results: Overall, 29 K. aerogenes, 77 E. cloacae and 337 K. pneumoniae BSI episodes were included. Mortality or recurrence was less frequent in K. aerogenes (6.9%) than in E. cloacae (20.8%) or K. pneumoniae (19.0%), but statistical difference was not observed (rate ratio (RR) 0.35, 95% CI 0.08 to 1.55; RR 0.42, 95% CI 0.10 to 1.71, respectively). Fever ≥ 72 h and device infection were more common in K. aerogenes group. In the multivariate analysis, adjusted for confounders (age, sex, BSI source, hospital ward, Charlson score and active antibiotic therapy), the estimates and direction of effect were similar to crude results. Conclusions: Results suggest that BSI caused by K. aerogenes may have a better prognosis than E. cloacae or K. pneumoniae BSI. © The Author(s) 2024.
PB BioMed Central Ltd
SN 1476-0711
YR 2024
FD 2024
LK http://hdl.handle.net/10498/33638
UL http://hdl.handle.net/10498/33638
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026