RT journal article
T1 Characterization of the histological changes in ovaries of Goto-Kakizaki diabetic rats
A1 Montero Peña,  Cristian
A1 Morales De Pando, José M.
A1 Díaz Gómez, Alfredo Luis
A1 González Medina, Gloria
A1 Ribelles García, Antonio
A1 Pérez Arana, Gonzalo Martín
A1 Prada Oliveira, José Arturo
A2 Anatomía y Embriología Humana
A2 Enfermería y Fisioterapia
K1 Goto-Kakizaki rats
K1 Type 2 diabetes mellitus
K1 Ovary
K1 Infertility
K1 Ovulatory dysfunction
K1 Polycystic ovary syndrome
AB Goto-Kakizaki (GK) rats are a useful animal model for studying type 2 diabetes mellitus (T2DM). However, this strain of rats exhibits poor fertility, so it is difficult to expand colonies. Based on previous studies, it was hypothesized that alterations in the oestrous cycle of diabetic rats are related to ovarian histology. The aim of this study was to determine the histology of the ovaries of diabetic rats compared to nondiabetic rats to understand the poor fertility of this strain of diabetic rats. An experimental study was thus conducted. Eight GK rats and eight Wistar rats were utilized. The rats were age-adjusted into two groups called “young rats” and “mature rats” at two and fourteen months of age, respectively. After sacrificing the rats, the ovaries were dissected and processed by fixation and paraffin embedding to perform the histological study. The results included the number of corpora lutea and the percentage of follicular fraction in each ovary, as well as qualitative data such as the presence of follicles in different stages of development. Our findings revealed differences between GK and Wistar rats. The ovarian histological findings were related to the presence of T2DM, polycystic ovary syndrome and poor fertility in female GK rats; the link between these pathologies is insulin resistance. Future lines of investigation into metabolic treatment, which may help improve insulin resistance, could also benefit the previously described pathologies in female GK rats.
PB Sociedad Anatomica Espanola
SN 2340-311X
YR 2024
FD 2024
LK http://hdl.handle.net/10498/33645
UL http://hdl.handle.net/10498/33645
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 08-nov-2026