RT journal article
T1 Association between childhood obesity, trace elements, and heavy metals: Recent discoveries and future perspectives
A1 González Domínguez, Alvaro
A1 Jurado Sumariva, Lucía
A1 González-Domínguez, Raúl
A2 BiomedicinaBiotecnología y Salud Pública
K1 childhood obesity
K1 interindividual variability
K1 metals
K1 trace elements
AB Trace elements and heavy metals play pivotal roles in health status by regulating a myriad of vital biological functions. Abnormal metal homeostasis has been linked to a constellation of pathogenic complications, including oxidative stress, inflammatory processes, dyslipidemia, and impaired insulin-mediated metabolism of carbohydrates, thereby increasing the odds of developing childhood obesity and related comorbidities. Herein, we provide a comprehensive revision of recent literature on the association between childhood obesity, trace elements, and heavy metals. Further, we emphasize on the crucial importance of addressing the influence that interindividual variability factors (e.g., sex, age, genetic determinants, concomitance of comorbidities, and environmental factors) may have in modulating the susceptibility to disease development. Altogether, this review article represents a concise guide to better understand the involvement of metals in childhood obesity pathogenesis and discusses future needs with the aim of establishing robust biomarkers in the context of precision medicine.
PB John Wiley and Sons Inc
SN 1467-789X
YR 2024
FD 2024
LK http://hdl.handle.net/10498/33647
UL http://hdl.handle.net/10498/33647
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 15-nov-2026