RT journal article T1 Game-Based Virtual Reality Interventions to Improve Upper Limb Motor Function and Quality of Life After Stroke: Systematic Review and Meta-analysis A1 Domínguez-Téllez, Pablo A1 Moral Muñoz, José Antonio A1 Salazar Couso, Alejandro A1 Casado Fernández, Esteban A1 Lucena Antón, David Manuel A2 Enfermería y Fisioterapia A2 Estadística e Investigación Operativa K1 Virtual reality K1 Stroke K1 Physical therapy K1 Meta-analysis AB Stroke is the main cause of disability in adulthood. Recent advances in virtual reality (VR) technologies have led to its increased use in the rehabilitation of stroke patients. A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to determine the effectiveness of game-based reality on upper limb (UL) motor function and quality of life after stroke. In March 2018, a search of the following databases was performed: PubMed, PEDro, Web of Science, Scopus, The Cochrane Library, and Medline at EBSCO. The selection criteria were all RCTs published in English or Spanish during the past 10 years. The PEDro scale was used to evaluate the methodological quality of the studies. A total of 20 clinical trials were included in the systemic review, of which 15 contributed information to the meta-analysis. Favorable results were found for VR interventions on UL motor function (Fugl-Meyer Assessment for upper extremity, standardized mean difference [SMD] = 1.53, 95% CI [0.51–2.54]) and quality of life (functional independence measure, SMD = 0.77, 95% CI [0.05–1.49]). The results demonstrate the potential benefits of VR interventions on the recovery of UL motor function and on quality of life after stroke. PB Mary Ann Liebert SN 2161-7856 YR 2020 FD 2020-02 LK http://hdl.handle.net/10498/33870 UL http://hdl.handle.net/10498/33870 LA eng DS Repositorio Institucional de la Universidad de Cádiz RD 09-nov-2026