RT journal article
T1 HIV antibodies level as a marker of HIV persistence: the role of hepatitis C virus coinfection
A1 Arca Suárez, Jorge
A1 Corrales-Cuevas, Manuel
A1 Pascual-Pérez, Susana
A1 Trujillo-Soto, Teresa
A1 Fernández-Gutiérrez del Álamo, Clotilde
A1 Rodríguez Iglesias, Manuel Antonio
A1 Girón González, José Antonio
A2 BiomedicinaBiotecnología y Salud Pública
A2 Medicina
K1 HCV infection
K1 HCV infection treatment
K1 HIV antibodies level
K1 HIV reservoir
AB Human immunodeficiency virus (HIV) antibodies have been proposed as a measure of the size of the HIV reservoir. The aim of our study is to quantify the anti-HIV antibodies level in a cohort of people living with HIV (PLWH), stratified based on the presence of continuous undetectable HIV viral load and the co-existence of hepatitis C virus infection. A sample of 229 HIV-monoinfected (n = 114) or HIV/HCV-coinfected [either with resolved HCV infection (n = 75) or active HCV coinfection (n = 40)] patients, followed up a median of 34 (IQR 20-44) months, was studied. Anti-HIV index was obtained as the 1:800 dilution of HIV antibodies. CD4+ T cell count, time with undetectable HIV viral load, annual increase of CD4+ T cell count, anti-HCV therapy, and diagnosis of cirrhosis were analyzed. Patients with a continued suppressed HIV viral load had significant lower anti-HIV index compared with those with virologic failure during the follow-up. Significant higher CD4+ T cell increase was observed in those with a lower anti-HIV index. HIV-monoinfected patients showed an anti-HIV index significantly lower than patients with HCV coinfection. Resolved HCV infection after interferon-based therapy, but not with direct acting antivirals, was associated with a lower anti-HIV index. HIV/HCV-coinfected patients showed higher HIV antibodies level when compared with HIV-monoinfected individuals. A decrease in anti-HIV index in HIV/HCV-coinfected patients was detected when a sustained virological HCV response was obtained after interferon-based therapy, in possible relation with the direct or indirect effect of interferon on PLWH CD4 T cells.
PB SPRINGER
SN 1435-4373
YR 2020
FD 2020
LK http://hdl.handle.net/10498/33874
UL http://hdl.handle.net/10498/33874
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 13-nov-2026