RT journal article
T1 Folate and Vitamin B12 concentrations are associated with plasma DHA and EPA fatty acids in European adolescents: The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study
A1 Iglesia, I.
A1 Huybrechts, I.
A1 González Gross, M.
A1 Mouratidou, T.
A1 Santabárbara, J.
A1 Chajès, V.
A1 González Gil, E. M.
A1 Park, J. Y.
A1 Bel Serrat, S.
A1 Cuenca García, María Magdalena
A1 Castillo, M.
A1 Kersting, M.
A1 Widhalm, K.
A1 De Henauw, S.
A1 Sjöström, M.
A1 Gottrand, F.
A1 Molnár, D.
A1 Manios, Y.
A1 Kafatos, A.
A1 Ferrari, M.
A1 Stehle, P.
A1 Marcos, A.
A1 Sánchez Muniz, F. J.
A1 Moreno, L. A.
A2 Didáctica de la Educación FísicaPlástica y Musical
K1 Fatty acids
K1 B-vitamins
K1 Adolescents
K1 Europe
AB This study aimed to examine the association between vitamin B6, folate and vitamin B12 biomarkers and plasma fatty acids in Europeanadolescents. A subsample from the Healthy Lifestyle in Europe by Nutrition in Adolescence study with valid data on B-vitamins and fatty acidblood parameters, and all the other covariates used in the analyses such as BMI, Diet Quality Index, education of the mother and physicalactivity assessed by a questionnaire, was selected resulting in 674 cases (43 % males). B-vitamin biomarkers were measured bychromatography and immunoassay and fatty acids by enzymatic analyses. Linear mixed models elucidated the association between B-vitaminsand fatty acid blood parameters (changes in fatty acid profiles according to change in 10 units of vitamin B biomarkers). DHA, EPA) and n-3fatty acids showed positive associations with B-vitamin biomarkers, mainly with those corresponding to folate and vitamin B12. Contrarily,negative associations were found with n-6:n-3 ratio, trans-fatty acids and oleic:stearic ratio. With total homocysteine (tHcy), all theassociations found with these parameters were opposite (for instance, an increase of 10 nmol/l in red blood cell folate or holotranscobalaminin females produces an increase of 15·85 µmol/l of EPA (P value <0·01), whereas an increase of 10 nmol/l of tHcy in males produces adecrease of 2·06 µmol/l of DHA (P value <0·05). Positive associations between B-vitamins and specific fatty acids might suggest underlyingmechanisms between B-vitamins and CVD and it is worth the attention of public health policies
PB Cambridge University Press
SN 1475-2662
YR 2017
FD 2017
LK http://hdl.handle.net/10498/34163
UL http://hdl.handle.net/10498/34163
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 11-nov-2026