RT journal article
T1 Structural and biosynthetic studies of botrycinereic acid, a new cryptic metabolite from the fungus Botrytis cinerea
A1 Pinto, Ana Andreina
A1 Barúa, Javier E.
A1 Almeida, Marilia O.
A1 Viaud, Muriel
A1 Zorrilla Cuenca, David
A1 González Collado, Isidro
A1 Macías Sánchez, Antonio José
A1 Durán Patrón, Rosa María
A2 Química Física
A2 Química Orgánica
K1 Botrytis cinerea
K1 Cryptic metabolite
K1 Epigenetic modifier
K1 SAHA
K1 Mutant
K1 Biosynthesis
AB Chemical epigenetic manipulation of Botrytis cinerea strain B05.10 with the histone deacetylase inhibitor SAHA led to the isolation of a new cryptic metabolite, botrycinereic acid (22a). This compound was also overproduced by inactivating the stc2 gene, which encodes an unknown sesquiterpene cyclase. Its structure and absolute configuration were determined by extensive spectroscopic NMR and HRESIMS studies, and electronic circular dichroism calculations. Its biosynthesis was studied by feeding 2H and 13C isotopically labeled precursors to B. cinerea Δstc2 mutant. A detailed analysis of the labeling and coupling patterns into botrycinereic acid (22a) revealed that this compound derives from L-phenylalanine and L-leucine.
PB Elsevier
SN 0045-2068
YR 2022
FD 2022
LK http://hdl.handle.net/10498/34243
UL http://hdl.handle.net/10498/34243
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 07-nov-2026