RT journal article
T1 Association Between Lifestyle Patterns and Abdominal Obesity with Biochemical and Inflammatory Biomarkers in Adolescents with Down Syndrome: The UP&DOWN Study
A1 Gutierrez-Hervas, Ana
A1 Nova, Esther
A1 Izquierdo Gómez, Rocío
A1 Veiga, Oscar
A1 Padilla Moledo, María del Carmen
A1 Castro Piñero, José
A1 Marcos, Ascensión
A1 Gómez Martínez, Sonia
A2 Didáctica de la Educación FísicaPlástica y Musical
K1 Down syndrome
K1 adolescents
K1 inflammatory biomarkers
K1 lifestyle patterns
AB Background/objectives: The main objective of this study was to examine the association between lifestyle patterns (physical activity, screen and sleep time and diet) and abdominal obesity, and endocrine, metabolic, and immunological biomarkers in adolescents with Down syndrome (DS).Methods: Eighty-three DS adolescents (38.6% girls), aged 11 to 18 years, from the UP&DOWN study were included. Cluster analysis was performed by including the compliance of recommendations of lifestyle variables, such as moderate to vigorous physical activity (MVPA), screen and sleep time and adherence to the Mediterranean diet (AMD). The waist-to-height ratio was used as an indicator of abdominal obesity. Haematological, biochemical and inflammatory biomarkers were analysed.Results: A three-cluster solution was identified: Cluster 1: adolescents with low compliance; Cluster 2: youth with medium compliance; and Cluster 3: adolescents with high compliance. Significant differences in MVPA (p = 0.000), screen time (p = 0.004), sleep time (p = 0.0001), AMD (p = 0.000) and abdominal obesity (p = 0.003) were found. Clusters 2 and 3 had lower levels of triglycerides and LDL-cholesterol than Cluster 1. Cluster 2, in which all adolescents met the MVPA recommendations, had the lowest levels of galactin 3.Conclusions: Compliance with lifestyle recommendations (PA, screen and sleep time and AMD) and the absence of abdominal obesity seem to be associated with better biochemical and inflammatory values
PB MDPI
SN 2072-6643
YR 2024
FD 2024-11-14
LK http://hdl.handle.net/10498/34284
UL http://hdl.handle.net/10498/34284
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 07-nov-2026