RT journal article
T1 Relationship between diabetic neuropathic pain and comorbidity. Their impact on pain intensity, diabetes complications and quality of life in patients with type-2 diabetes mellitus.
A1 Naranjo, Cristina
A1 Ortega Jiménez, Patricia
A1 Del Reguero, Leticia
A1 Moratalla, Guillermo
A1 Failde Martínez, Inmaculada
A2 BiomedicinaBiotecnología y Salud Pública
A2 Estadística e Investigación Operativa
K1 Diabetic neuropathic pain
K1 Mental disorders
K1 Sleep disorders
AB ObjectiveTo compare cognitive function, mood and sleep status in patients with and without diabetic neuropathic pain (DNP) and their relationship with pain intensity, diabetes complications, and quality of life. To determine whether these relationships differ depending on the sensorial phenotype.MethodsCross-sectional study performed on patients with type-2 diabetes-mellitus and neuropathy. Presence of DNP, pain intensity and phenotype, mood status, sleep characteristics and quality of life were measured.ResultsA total of 130 patients (65 with DNP) were included. DNP was related to poor sleep quality (OR = 1.03;CI95%:1.02–1.05), pain treatment (OR = 3.00,CI95%:1.24–7.29) or previous anxiety (OR = 2.70,CI95%:1.05–6.99). Patients with specific phenotypes or depression (=0.82,CI95%:−0.02–1.67) referred more severe pain. More complications were related to older age (OR = 1.40,CI95%:1.12–1.66), higher pain intensity (OR = 1.51,CI95%:1.00–2.28), lower cognitive performance (OR = 1.25,CI95%:1.09–1.43), previous anxiety (OR = 10.48,CI95%:1.46–75.24) and insulin treatment (OR = 124.50,CI95%:6.64–2335.06). Decrease in mental quality of life was associated with sleep disorders (β = −0.33,CI95%:−0.48,−0.23), physical comorbidities (β = −9.73,CI95%:−18.15, −1.31) and previous anxiety (β = −7.91,CI95%:−13.04, −2.77). Lower scores in physical quality of life were related to sleep disorders (β = −0.12,CI95%:−0.21, −0.18), obesity (β = −8.35,CI95%:−13.16, −3.55), longer time since diagnosis (β = −0.72,CI95%:−1.44;0.01) and disability (β = −14.58,CI95%:−24.69; −4.48).ConclusionsThe results support the idea that mental comorbidity and sleep disorders are factors associated with DNP and greater pain intensity, more diabetes complications and lower quality of life. Moreover, they highlight the relationship between sensorial phenotypes and pain intensity, and lower cognitive performance and diabetes complications.
PB Elsevier
SN 1872-8227
YR 2020
FD 2020-07-20
LK http://hdl.handle.net/10498/34303
UL http://hdl.handle.net/10498/34303
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-may-2026