RT journal article
T1 Inflammation and fatness in adolescents with and without Down Syndrome. UP&DOWN Study
A1 Gutierrez-Hervas, Ana
A1 Gómez Martínez, Sonia
A1 Izquierdo Gómez, Rocío
A1 Veiga, Oscar
A1 Perez Bey, Alejandro
A1 Castro Piñero, José
A1 Marcos, Ascensión
A2 Didáctica de la Educación FísicaPlástica y Musical
K1 Down syndrome
K1 adiposity
K1 adolescents
K1 inflammatory biomarkers
AB Background: The main objective of this study was to describe the inflammatory status of adolescents with Down syndrome (DS) and their relationship with adiposity.Methods: Ninety-five adolescents with DS (44.2% girls) and a control group of 113 adolescents (47.8% girls), aged between 11 and 18 years old, from the UP & DOWN study were included in this substudy. Serum C-reactive protein, C3 and C4 complement factors, total proteins, interleukin-6, tumour necrosis factor-α, insulin, cortisol, leptin, adiponectin, galactin-3 and visfatin were analysed; homeostatic model assessment index was calculated. In order to evaluate adiposity, we measured the following body fat variables: weight, height, waist circumference and skinfold thicknesses. Birth weight was obtained by questionnaire. In addition, body mass index, waist-to-height ratio (WHtR) and body fat percentage (BF%) were calculated.Results: Down syndrome group showed higher levels of body mass index, WHtR, waist circumference, BF% and lower birth weight than controls (P < 0.001). In the general linear model in the total sample, WHtR was positively associated with C3 and C4 (P < 0.001) as well as with leptin levels (P = 0.015). BF% was positively associated with total proteins (P = 0.093) and leptin levels (P < 0.001). DS was positively associated with total proteins (P < 0.001), C3 (P = 0.047) and C4 (P = 0.019). Despite the higher levels of adiposity found in DS group, no direct association was found between BF% and leptin levels, comparing with the control group.Conclusions: These findings suggest that abdominal obesity should be controlled in adolescents because of its relationship with acute phase-inflammatory biomarkers but especially in DS adolescents who may show a peculiar metabolic status according to their relationship between adiposity and inflammatory biomarkers
PB Wiley
SN 1365-2788
YR 2020
FD 2020
LK http://hdl.handle.net/10498/34329
UL http://hdl.handle.net/10498/34329
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 11-nov-2026