RT journal article
T1 Does the activation of sea bass GnIH receptor modulate GnRH receptor signaling?
A1 Wang, Bin
A1 Paullada Salmerón, José Antonio
A1 Verges Castillo, Alba
A1 Muñoz Cueto, José Antonio
A2 Biología
K1 GnIH
K1 GnRH
K1 GnIH receptor
K1 GnRH receptor
K1 PKA signaling pathway
AB Previous studies have revealed the stimulatory and inhibitory actions of gonadotropin-releasing hormone (GnRH) and gonadotropin-inhibitory hormone (GnIH) on the control of reproduction in European sea bass (Dicentrarchus labrax) and other vertebrates, respectively. However, information on the possible interactions between GnRH and GnIH on cell signaling is sparse in vertebrates. In the current study, we investigated if activation of sea bass GnIH receptor (GnIHR) can interfere with GnRH receptor II-1a (GnRHR-II-1a) involving the PKA pathway. Our results showed that GnIH and GnRH functioned via their cognate receptors, respectively. However, it appears that neither GnIH1 nor GnIH2 can block GnRH/GnRHR-II-1a-induced PKA signaling in sea bass. This is the first study to examine the potential interactions of GnIH with GnRH receptor signaling in teleosts. Further research seems necessary to shed light on unknown interactions in other signaling pathways and other GnIH/GnRH receptors involved in the physiological functions of these two relevant neuropeptides, not only in sea bass but also in other species.
PB Elsevier
SN 1531-4332
YR 2024
FD 2024-10
LK http://hdl.handle.net/10498/34418
UL http://hdl.handle.net/10498/34418
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 05-nov-2026