RT journal article
T1 Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals
A1 Coleman, J.R.I.
A1 Bryois, J.
A1 Gaspar, H.A.
A1 Jansen, P.R
A1 Savage, J.E.
A1 Skene, N.
A1 Plomin, R
A1 Muñoz Manchado, Ana Belén
A2 Neurociencias
K1 Gwas
K1 intelligence
K1 metadata
K1 neurons
K1 cortex
AB Variance in IQ is associated with a wide range of health outcomes, and 1% of the population are affected by intellectual disability. Despite a century of research, the fundamental neural underpinnings of intelligence remain unclear. We integrate results from genome-wide association studies (GWAS) of intelligence with brain tissue and single cell gene expression data to identify tissues and cell types associated with intelligence. GWAS data for IQ (N = 78,308) were meta-analyzed with a study comparing 1247 individuals with mean IQ ~170 to 8185 controls. Genes associated with intelligence implicate pyramidal neurons of the somatosensory cortex and CA1 region of the hippocampus, and midbrain embryonic GABAergic neurons. Tissue-specific analyses find the most significant enrichment for frontal cortex brain expressed genes. These results suggest specific neuronal cell types and genes may be involved in intelligence and provide new hypotheses for neuroscience experiments using model systems.
SN 1476-5578
YR 2019
FD 2019-02
LK http://hdl.handle.net/10498/34480
UL http://hdl.handle.net/10498/34480
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-may-2026