RT journal article
T1 Respiratory deficits in a female rat model of Parkinson's disease
A1 de la Rosa, Tomás
A1 Sanabria, Viviam
A1 Gonçalves, Valeria Cassia
A1 Ferreira, Caroline B
A1 Cabral, Lais M
A1 Souza, Felipe
A1 Amado, Debora
A1 Scorza, Fúlvio A
A1 Moreira, Thiago
A1 Takakura, Ana Carolina
A2 Neurociencias
K1 6OHDA
K1 breathing
K1 hypercapnia
K1 hypoxia
K1 ovariectomy
AB Emerging evidence indicates that the course of Parkinson’s disease (PD) includes auto-nomic and respiratory deficiencies in addition to the classical motor symptoms. Theprevalence of PD is lower in women, and it has been hypothesized that neuroprotectionby ovarian hormones can explain this difference. While male PD animal models pre-sent changes in the central respiratory control areas, as well as ventilatory parametersunder normoxia and hypercapnia, little is known about sex differences regardingrespiratory deficits in this disease background. This study aimed to explore the neuro-anatomical and functional respiratory changes in intact and ovariectomized (OVX)female rats subjected to chemically induced PD via a bilateral intrastriatal injectionof 6-hydroxydopamine (6-OHDA). The respiratory parameters were evaluated bywhole-body plethysmography, and the neuroanatomy was monitored using immuno-histochemistry. It was found that dopaminergic neurons in the substantia nigraand neurokinin-1 receptor density in the rostral ventrolateral respiratory group,Bötzinger and pre-Bötzinger complex were reduced in the chemically induced PDanimals. Additionally, reduced numbers of Phox2b neurons were only observed in theretrotrapezoid nucleus of PD-OVX rats. Concerning respiratory parameters, in OVXrats, the resting and hypercapnia-induced tidal volume (VT ) is reduced, and ventilation(̇ VE ) changes independently of 6-OHDA administration. Notably, there is a reductionin the number of retrotrapezoid nucleus Phox2b neurons and hypercapnia-inducedrespiratory changes in PD-OVX animals due to a 6-OHDA and OVX interaction. Theseresults suggest a protective effect induced by ovarian hormones in neuroanatomicalchanges observed in a female experimental PD model.
PB The Physiological Society
SN 0958-0670
YR 2022
FD 2022
LK http://hdl.handle.net/10498/34481
UL http://hdl.handle.net/10498/34481
LA eng
NO This work was supported by the following grants: São Paulo Research Foundation (FAPESP; grants: 2019/01236-4 to ACT; 2015/23376-1 to T.S.M.); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; grant: 408647/2018-3 to A.C.T.). This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001.
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-may-2026