RT journal article
T1 Potential of environmental concentrations of the musks galaxolide and tonalide to induce oxidative stress and genotoxicity in the marine environment
A1 Ehiguese, Friday Ojie
A1 Alam, M R
A1 Pintado Herrera, Marina Guadalupe
A1 Araújo, Cristiano V.M.
A1 Martín Díaz, María Laura
A2 Química Física
AB Polycyclic musk compounds have been identified in environmental matrices (water, sediment and air) and in biological tissues in the last decade, yet only minimal attention has been paid to their chronic toxicity in the marine environment. In the present research, the clams Ruditapes philippinarum were exposed to 0.005, 0.05, 0.5, 5 and 50 μg/L of the fragrances Galaxolide® (HHCB) and Tonalide® (AHTN) for 21 days. A battery of biomarkers related with xenobiotics biotransformation (EROD and GST), oxidative stress (GPx, GR and LPO) and genotox icity (DNA damage) were measured in digestive gland tissues. HHCB and AHTN significantly (p < 0.05) induced EROD and GST enzymatic activities at environmental concentrations. Both fragrances also induced GPx activity.All concentrations of both compounds induced an increase of LPO and DNA damage on day 21. Although these substances have been reported as not acutely toxic, this study shows that they might induce oxidative stress and genotoxicity in marine organisms.
PB Elsevier
SN 1879-0291
YR 2020
FD 2020-05-16
LK http://hdl.handle.net/10498/34561
UL http://hdl.handle.net/10498/34561
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 21-sep-2026